Đến tháng 2 năm 2008, các hãng hàng không sau đây hoạt động tại Sân bay quốc tế Cairo:

• Aegean Airlines (Athens)
• Aeroflot (Moscow-Sheremetyevo)
• Afriqiyah Airways (Tripoli)
• Air Algérie (Algiers)
• Air France (Paris-Charles de Gaulle)
• Air Malta (Luqa) [seasonal]
• Air Sinai (Tel Aviv)
• Alexandria Airlines (Alexandria, Aqaba, Luxor and other charter destinations)
• Alitalia (Milan-Malpensa, Rome-Fiumicino)
• Austrian Airlines (Vienna)
• AMC Airlines (Istanbul-Sabiha Gokcen, Luxor, Paris-Charles de Gaulle, Sharm El Sheikh and various charter routes - nội địa và quốc tế)
• British Airways (London-Heathrow)
• Buraq Air (Tripoli)
• Croatia Airlines (Zagreb) (từ 02.05.08)
• Cairo Aviation (various charter routes - nội địa và quốc tế)
• Cyprus Airways (Larnaca)
• Czech Airlines (Prague)
• Delta Air Lines (New York-JFK)(từ 04.06.08)
• EgyptAir (Abu Dhabi, Abu Simbel, Accra, Addis Ababa, Aleppo, Alexandria, Algiers, Amman, Amsterdam, Asmara, Assiut, Aswan, Athens, Bahrain, Bangkok-Suvarnabhumi, Barcelona, Beijing, Beirut, Benghazi, Berlin-Schönefeld, Brussels, Budapest, Casablanca, Damascus, Dammam, Doha, Dubai, Düsseldorf, Entebbe, Frankfurt, Geneva, Guangzhou, Hurghada, Istanbul-Atatürk, Jeddah, Johannesburg, Kano, Khartoum, Kuala Lumpur, Kuwait, Lagos, Larnaca, Lisbon, London-Heathrow, Luxor, Kuwait, Madrid, Madina, Milan-Malpensa, Moscow-Domodedovo, Mumbai, Munich, Muscat, Nairobi, New York-JFK, Osaka-Kansai, Paphos, Paris Charles-de-Gaulle, Riyadh, Rome-Fiumicino, Sanaa, Sharjah, Sharm El Sheikh, Tokyo-Narita, Tripoli, Tunis, Vienna)
• EgyptAir Express (Alexandria, Aswan, Hurghada, Luxor, Mersa Metruh, Marsa Alam, Sharm El Sheikh)
• El Al (Tel Aviv)
• Emirates (Dubai)
• Ethiopian Airlines (Addis Ababa, Khartoum)
• Etihad Airways (Abu Dhabi)
• Eurocypria Airlines (Paphos)
• Gulf Air (Abu Dhabi, Bahrain, Muscat)
• Iberia Airlines (Barcelona, Madrid)
• Iraqi Airways (Baghdad)
• Jetairfly (Brussels)
• Kenya Airways (Khartoum, Nairobi)
• KLM (Amsterdam)
• Koral Blue Airlines (Hurghada, Sharm el Sheikh)
• Korean Air (Seoul-Incheon)
• Kuwait Airways (Kuwait)
• Libyan Airlines (Benghazi, Sebha, Tripoli)
• Lotus Air (Gdansk, Hurghada, Paris-Charles de Gaulle, Sharm el Sheikh, Warsaw)
• Lufthansa (Frankfurt)
• Luxor Air (various charter routes - nội địa và quốc tế)
• Middle East Airlines (Beirut)
• Nile Air (launches in 2008)
• Olympic Airlines (Athens)
• Oman Air (Muscat)
• Petroleum Air Services (various domestic airports and oilfield airstrips)
• Qatar Airways (Doha)
• Royal Air Maroc (Casablanca, Riyadh)
• Royal Jordanian (Amman, Aqaba)
• Saudi Arabian Airlines (Dammam, Jeddah, Madina, Riyadh)
• Singapore Airlines (Singapore)
• Sudan Airways (Khartoum, Port Sudan)
• Swiss International Air Lines (Zürich)
• Syrian Arab Airlines (Aleppo, Damascus, Latakia)
• TAROM (Amman, Bucharest-Otopeni)
• Turkish Airlines (Istanbul-Atatürk)
• TUIfly (Berlin-Tegel, Cologne/Bonn, Munich)
• Tunis Air (Tunis)
• Uzbekistan Airways (Tashkent)
• Yemenia (Aden, Sanaa)

Cargo airlines

• Egyptair Cargo (Frankfurt-Hahn, Kharthoum, Sharjah, Bordeaux, Ostend, London-Stansted)
• Tristar Air (Los Angeles, New York-LaGuardia, Manston, Sharm El Sheikh)
• Royal Jordanian (Amman, Aqaba)
• Air France Cargo(Paris-Charles de Gaulle, Lyon, Marseille)
• Saudi Arabian Airlines (Medinah, Riyadh, Jeddah, Dammam)
• Ethiopian Airlines (Addis Abeba)
• Thai Airways International (Bangkok-Suvarnabhumi, Phuket, Karachi)
• DAS Air Cargo (Manston)
• Lufthansa Cargo (Frankfurt)
• MK Airlines Cargo (Manston, Ostend)